This Keto Buffalo Chicken Casserole recipe is all about bringing the taste of buffalo wings right to your dinner table without the carbs! We're talking juicy chicken, crispy bacon, creamy buffalo sauce, and mouthwatering spices, all whipped up into one easy-to-make, low-carb casserole. So, let's get cooking and whip up this cheesy delight that's perfect for any keto diet!

Jump to:
- Preparation and cooking overview
- Chef's note
- 🥘 Ingredients for this keto buffalo chicken casserole recipe
- Ingredient substitutions
- Additional ingredients
- Cooking tools required
- Tools substitute options
- How to make Keto Buffalo Chicken Casserole: step-by-step guide
- Cooking methods
- Preparation steps
- Cooking instructions
- What to serve with keto buffalo chicken casserole?
- How to make it healthier
- Time-saving tips
- What can I prepare ahead of time?
- Storage and reheating instructions
- Recipe wrap-up and conclusion
- Frequently asked questions
- 📖 Recipe
Preparation and cooking overview
Crafting this Buffalo Chicken Casserole is as easy as pie. You'll start with getting your spaghetti squash tender in the microwave, followed by pan-frying your bacon and chicken to perfection. In just under an hour, you've whipped up a cheesy, flavorful casserole that doesn't skimp on taste or satisfaction - it's keto cooking at its best!
Chef's note
Add a teaspoon of smoked paprika or cayenne pepper to enhance the spice level. You can also add ranch seasoning to the casserole mix for a tangy and herby flavor. The blend of buffalo sauce and ranch seasoning is like bringing home the classic taste of spicy hot wings dipped in cool, creamy ranch!
🥘 Ingredients for this keto buffalo chicken casserole recipe
Here is a simple ingredient list for this chicken dish:
Ingredient substitutions
Additional ingredients
Add some optional ingredients to enhance the flavor profile of your casserole.
Cooking tools required
To make this Keto Buffalo Chicken Casserole recipe, you will need the following kitchen tools:
Tools substitute options
How to make Keto Buffalo Chicken Casserole: step-by-step guide
Cooking methods
Preparation steps
- First, gather all the ingredients listed in the recipe. Measure them in needed quantities and set them aside.
- Wash the vegetables with cold water and set them aside.
- Slice 3 jalapeños.
- Grate the cheese and keep it covered in the refrigerator until ready to use.
Cooking instructions
- Prepare spaghetti squash: To microwave spaghetti squash properly, cut the squash in half lengthwise and remove the seeds. Poke holes in it with the help of a fork. Place the halves in a microwave-safe bowl and cook for 12-15 minutes until they become tender. Once cooked, use a fork to scoop the strands and transfer them to a colander to drain any excess moisture.
- Fry the bacon: Heat a large 10.5″ skillet over medium heat and fry the bacon until crispy. Remove, chop, and set aside.
- Fry the chicken: Sprinkle onion powder and garlic powder on the fillet, then place it in a heated, oiled skillet. Cook the chicken for about 5 minutes per side until crispy and cooked. Remove to a cutting board and chop into small bite-sized pieces.
- Ready the casserole: In the same pan, add sliced jalapeños and saute for 30 seconds. Add in the cream cheese, sour cream, and buffalo sauce. Mix until melted. Next, toss in the spaghetti squash, bacon, and chicken. Pour in the beaten egg and mix everything thoroughly.
- Bake the mix: Sprinkle shredded cheese over the mixture in the skillet. Place the skillet in the preheated oven at 375° and bake for 30 minutes.
- Serve: Once the casserole is cooked, remove it from the oven. Top it with any desired additional toppings before serving.

Chef's pro tip
Drain the microwaved spaghetti squash thoroughly before adding it to the other ingredients to avoid a soggy casserole. This will remove excess moisture and prevent the casserole from having a runny texture.
What to serve with keto buffalo chicken casserole?
This recipe provides a complete meal on its own. But if you want something more, you can pair it with the following options:
How to make it healthier
Time-saving tips
What can I prepare ahead of time?
Storage and reheating instructions
This low-carb chicken casserole is your new best friend when it comes to meal prep. If you're hustling and bustling, just double up on the recipe and whip up a big batch. Voila, you've got a ready-to-eat snack at your fingertips whenever you're on the move!
Storage tips
Reheating tips
Recipe wrap-up and conclusion
This Keto Buffalo Chicken Casserole is undoubtedly a game changer for anyone seeking cozy, comfort food that's low in carbs. So, say hello to your spicy comfort fusion and let this dish become a regular on your keto meal plan. And hey, don't be shy! Snap a photo of your masterpiece and make sure to tag us on Instagram and Facebook – we love seeing your creations!
Looking for more keto-friendly buffalo chicken recipes?
Frequently asked questions
📖 Recipe

Keto Buffalo Chicken Casserole
Ingredients
- 1 medium spaghetti squash 19 ounces of "noodles"
- 1.5 pounds boneless skinless chicken thighs
- 6 slices bacon
- 4 jalapeños thinly sliced
- 8 ounces of cream cheese
- ¼ cup sour cream
- 2 cups Mexican blend cheese
- ½ cup buffalo sauce
- ½ teaspoon onion powder
- ½ teaspoon garlic powder
- 3 large eggs
Instructions
- Prepare spaghetti squash: To microwave spaghetti squash properly, cut the squash in half lengthwise and remove the seeds. Poke holes in it with the help of a fork. Place the halves in a microwave-safe bowl and cook for 12-15 minutes until they become tender. Once cooked, use a fork to scoop the strands and transfer them to a colander to drain any excess moisture.
- Fry the bacon: Heat a large 10.5″ skillet over medium heat and fry the bacon until crispy. Remove, chop, and set aside.
- Fry the chicken: Sprinkle onion powder and garlic powder on the fillet, then place it in a heated, oiled skillet. Cook the chicken for about 5 minutes per side until crispy and cooked. Remove to a cutting board and chop into small bite-sized pieces.
- Ready the casserole: In the same pan, add sliced jalapeños and saute for 30 seconds. Add in the cream cheese, sour cream, and buffalo sauce. Mix until melted. Next, toss in the spaghetti squash, bacon, and chicken. Pour in the beaten egg and mix everything thoroughly.
- Bake the mix: Sprinkle shredded cheese over the mixture in the skillet. Place the skillet in the preheated oven at 375° and bake for 30 minutes.
- Serve: Once the casserole is cooked, remove it from the oven. Top it with any desired additional toppings before serving.
Linda says
What is buffalo sauce?
Alex Lester says
We use Franks Red Hot, it's just hot sauce really.
Christie says
I made this last night and it was absolutely AMAZING! Thank you for posting a new recipe!
Lulu says
Made this tonight to use up rotisserie cooked chicken, so I added the onion & garlic powders to the sauce. Very nice comfort food in winter! I used Frank's Buffalo Wing Sauce and halved the recipe for a 9x9 casserole but I left out the sour cream. Needed an extra 10min baking to set. A very nice dinner with a salad. FYI - squash haters won't even taste it.
Shannon says
I made this tonight and OMG it is delicious! I am not usually crazy about spaghetti squash but I took a chance and it is a keeper recipe.
Alex Lester says
Awesome, happy you liked it!
Rach says
This is so good. I made it minus the eggs, cheese and jalapeño (we are light-weights). So filling!!!
Amy says
Can you roast the squash instead of microwaving? Thanks!
Alex Lester says
Yes!
Barbara Murphy says
Can you freeze this?
Alex Lester says
Yes!
Jacki says
This was so yummy and super filling. This will be going into our rotation. I have loved all of the dishes I have made from Cast Iron Keto! Please keep them coming.
Judy A Fitzsimonds says
This was so, so good! Thank you!